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American Journal of Clinical Nutrition, Vol 24, 841-847, Copyright © 1971 by The American Society for Clinical Nutrition, Inc.

The role of urinary tryptophan metabolites in the etiology of bladder cancer

George T. Bryan M.D., Ph.D., F.A.C.P.1

1 From The Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Available experimental data obtained from a variety of approaches suggest that tryptophan and its urinary metabolites may be involved as one of several coordinated factors in urinary bladder carcinogenesis. When viewed with the evidence obtained from a quantitative examination of urinary tryptophan metabolites of patients with bladder carcinoma, the hypothesis that these metabolites may play a role in the genesis of human bladder cancer becomes more convincing. No substantial evidence to refute this hypothesis has been presented. However, it is equally clear that much work remains to be done to completely understand the events involved.






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Copyright © 1971 by The American Society for Nutrition