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American Journal of Clinical Nutrition, Vol 24, 792-799, Copyright © 1971 by The American Society for Clinical Nutrition, Inc.

Hormonal alteration of efficiency of conversion of tryptophan to urinary metabolites of niacin in man

Hans Wolf 1

1 From Division of Clinical Oncology, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53706

The influence of an anovulatory drug, estrogens, gestogens, and hydrocortisone on the conversion of a loading dose of 2 g l-tryptophan to urinary metabolites of nicotinic acid was studied in human male subjects with prostatic diseases. Estrogens and the anovulatory drug were found to increase the amount of the loading dose of tryptophan that could be accounted for as N1-methylnic-otinamide and N-methyl-2-pyridone-5-carboxamide in the urine. Gestogens alone and hydrocortisone, on the other hand, were found to have the opposite effect. On the basis of these findings, a hormonal control of NAD biosynthesis from tryptophan in man is proposed.






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Copyright © 1971 by The American Society for Nutrition