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American Journal of Clinical Nutrition, Vol 24, 388-393, Copyright © 1971 by The American Society for Clinical Nutrition, Inc.

Effect of a alpha-tocopherol administration on red cell survival in vitamin E-deficient human subjects

Patrick J. Leonard M.Sc., Ph.D.1 and Monty S. Losowsky M.D., F.R.C.P.1

1 From the Department of Medicine, St. James's Hospital, Leeds, LS9 7TF, England

The effect of agr-tocopherol therapy on red cell survival using 51Cr-tagged cells was studied in eight subjects with evidence of vitamin E deficiency.

In five of the eight subjects the survival curve was fitted significantly better by two straight lines than by one. Of the remaining three subjects, the Tfrac12 was initially within the normal range in one; the value was only just below normal in the second; and in the third, a normal plasma vitamin E level was not achieved by therapy.

Before the start of therapy the Tfrac12 for 51Cr in all eight subjects ranged from 10 to 28 days with a mean of 19.2 days. Following therapy, the values ranged from 19 to 30 days with a mean of 24.9 days, which is significantly different from the pretreatment value (P < 0.025).




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Copyright © 1971 by The American Society for Nutrition