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American Journal of Clinical Nutrition, Vol 21, 715-722, Copyright © 1968 by The American Society for Clinical Nutrition, Inc.

Effects of Orally Administered N-Acetyl-l-Cysteine and N-Acetyl-dl-Penicillamine on Vitamin B6 Availability and Copper Excretion in the Rat

J. C. CAPPS PH.D.1, E. M. MEDLER B.S.1, L. W. JACOBS 1, and A. L. SHEFFNER PH.D.1

1 From the Department of Biochemistry, Mead Johnson Research Center, Evansville, Indiana

The effect of N-acetyl-l-cysteine and N-acetyl-dl-penicillamine upon vitamin B6 availability was studied in rats. The sulfhydryl compounds were administered orally for 6 weeks and vitamin B6 availability was evaluated from studies of weight gain, food efficiency, xanthurenic acid excietion after a tryptophan load, serum and liver transaminase levels, and vitamin B6 excretion in the urine. In addition, the effect of these thiols on copper excretion in the urine was measured.

The results indicate that neither compound influenced the availability of vitamin B6 in the rat at dose levels per kilogram body weight as high as 10 times that used clinically. N-Acetyl-l-cysteine and N-acetyl-dl-penicillamine were also ineffective as copper-chelation agents. The known antivitamin B6 and copper-chelation properties of dl-penicillamine were demonstrated. The lack of effect of N-acetyl-dl-penicillamine on the parameters studied indicates that this compound is not deacetylated by the rat to penicillamine.






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Copyright © 1968 by The American Society for Nutrition