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American Journal of Clinical Nutrition, Vol 20, 1004-1009, Copyright © 1967 by The American Society for Clinical Nutrition, Inc.

Intestinal Folate Conjugase Activity in Tropical Sprue

FREDERICK A. KLIPSTEIN M.D.1

1 From Department of Medicine, Columbia University College of Physicians and Surgeons, the Francis Delafield Hospital, New York City, and the Hôpital Albert Schweitzer, Deschapelles, Haiti

Duodenal aspirates obtained from 25 Haitian subjects have been tested for the presence of folate conjugase activity by determining their capacity to release monoglutamate folate activity from egg yolk, a natural source of polyglutamate activity. Evidence of conjugase activity was detected in aspirates from 5 of 10 patients with tropical sprue and from 7 of 15 other subjects. Whether this enzyme is present in sufficient quantity in the succus entericus to deconjugate a physiologically significant quantity of dietary polyglutamate folate activity is uncertain.






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Copyright © 1967 by The American Society for Nutrition