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American Journal of Clinical Nutrition, Vol 16, 436-439, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Studies on Creatinine Metabolism in Kwashiorkor and Marasmus

S. G. SRIKANTIA M.B.B.S., D.SC.1, V. U. PARGAONKAR M.B.B.S.1, and VINODINI REDDY M.B.B.S., D.C.H.1

1 From the Nutrition Research Laboratories, Indian Council of Medical Research, Tarnaka, Hyderabad-7 (A.P.), India

Serum concentration of guanidineacetic acid arginine, creatine and creatinine in children suffering from kwashiorkor was low and increased with therapy. The concentration of all these compounds was higher in children suffering from marasmus.

Giving supplements of arginine and glycine to children with kwashiorkor caused an increase in the serum levels of all these compounds, both at the time of admission and after therapy, the increase being of a higher magnitude when the supplements were given after therapy. These changes, however, were not associated with parallel increases in urinary creatinine.

A high degree of correlation was observed between guanidineacetic acid levels and creatinine in serum.

The results of the study suggest that low serum levels of precursor compound account partly for the low serum creatinine levels seen in kwashiorkor.






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Copyright © 1965 by The American Society for Nutrition