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American Journal of Clinical Nutrition, Vol 16, 287-291, Copyright © 1965 by The American Society for Clinical Nutrition, Inc.

Studies on Cortisone-Induced Osteoporosis

I. Estimation of Daily Calcium Intake from Diet History and Seven Day Dietary Record

BJÖRN ISAKSSON M.D.1, BJÖRN LINDHOLM M.D.1, and GUNILLA CARLGREN 1

1 From the Department of Medicine II and Department of Allergology, University of Göteborg, Sahlgren's Hospital, Göteborg, Sweden

Forty-four freely ambulant patients with severely chronic asthma who had undergone longterm cortisone treatment were subjected to a dietary study. In twenty-two patients roentgenologically verified osteoporosis had developed during the course of treatment. The control subjects who were matched to the patients with osteoporosis with respect to sex, age and dose of cortisone, had no signs of the disease although their treatment period was considerably longer. The data were collected from dietary histories as well as from seven day dietary records. Agreement between the results obtained from the two methods was very good.

The mean calcium intake in the group with osteoporosis was 750 mg. per day and in the control group 901 mg. per day. The difference was not statistically significant. These intakes are lower than the total mean consumption in Sweden. This may be of significance in combination with disturbances induced by cortisone. Further studies, including among other things intestinal calcium absorption, will be conducted.






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Copyright © 1965 by The American Society for Nutrition