AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 15, 322-330, Copyright © 1964 by The American Society for Clinical Nutrition, Inc.

The Essential Amino Acid Requirements of Infants

X. Methionine

SELMA E. SNYDERMAN M.D.1, AUDREY BOYER 1, PATRICIA M. NORTON 1, ELLEN ROITMAN 1, and L. EMMETT HOLT JR. M.D.1

1 From the Department of Pediatrics, New York University School of Medicine, New York, New York

A synthetic diet which provides nitrogen as a mixture of eighteen l-amino acids was used to determine the methionine requirement of seven healthy infants. It ranged between 32 and 49 mg. per kg. day. Withdrawal of methionine from the diet resulted in marked changes in the plasma aminogram. These included a rise in the threonine, serine, proline, tyrosine and phenylalanine levels as well as a fall in the plasma methionine level. A decrease in the plasma cholesterol level was often associated with a suboptimal intake of methionine.




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