American Journal of Clinical Nutrition, Vol 15, 59-66, Copyright © 1964 by The American Society for Clinical Nutrition, Inc.

Vitamin B₆ Requirement for Adult Men

¹ From the U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado

The results of a study with young adult male subjects has revealed that (1) a vitamin B₆ depletion could be rapidly achieved, as was noted by measurements of urinary xanthurenic acid excretion following the oral administration of a 10 gm. dl-tryptophan load; (2) the rate of depletion was directly related to protein intake; (3) the changes in urinary vitamin B₆ excretion correlate inversely with the xanthurenic acid excretion and the deficiency status; (4) the 3-hydroxykynurenine excretion was of limited use in evaluating vitamin B₆ requirements; and (5) the urinary oxalate excretion showed little or no change. It is concluded that the optimal daily vitamin B₆ requirement (as pyridoxine hydrochloride) for subjects on a high protein intake (100 gm.) appeared to be 1.75 to 2.0 mg. per day, while subjects on a low protein intake (30 gm.) appeared to have a requirement of 1.25 to 1.5 mg. per day.

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