AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 13, 285-290, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Effects of Large Doses of l-Leucine in Animals and Man

LLOYD G. MCARTHUR M.D., PH.D.1, W. R. KIRTLEY M.D.1, and S. O. WAIFE M.D.1

1 From The Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Ind.

Normal human subjects and dogs responded to l-leucine with hypoglycemia when it was given orally in a large enough dose (approximately 750 mg. per kg.). Rats, however, failed to respond at this dose level. The lowest level of blood sugar corresponded in time with the peak of the plasma alpha amino nitrogen concentration. Why some people are sensitive to leucine and will respond to a relatively small dose (150 mg. per kg.), while others require a much larger dose, is still unknown.






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Copyright © 1963 by The American Society for Nutrition