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American Journal of Clinical Nutrition, Vol 13, 169-172, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Response of Macrocytic Anemia in Children to the Coenzyme Q4-Chromanol

JAMES S. DINNING PH.D.1, AMIN S. MAJAJ M.D.1, SAMIR A. AZZAM M.D.1, WILLIAM J. DARBY M.D.1, CLIFFORD H. SHUNK PH.D.1, and KARL FOLKERS PH.D.1

1 From the Department of Pediatrics, Augusta Victoria Hospital, Jerusalem, Jordan

Four children with macrocytic anemia have been treated with the 6-chromanol of hexahydrocoenzyme Q4. Urinary creatine-creatinine ratios were reduced following treatment in three of these patients. Following Q4-chromanol treatment, reticulocytes increased with improvement in the anemia, and the bone marrow changed from predominantly megaloblastic to predominantly normoblastic. Q4-chromanol treatment resulted in dramatic reduction in the previously elevated mean corpuscular volumes.




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