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American Journal of Clinical Nutrition, Vol 12, 49-53, Copyright © 1963 by The American Society for Clinical Nutrition, Inc.

Vanadium

Excretion, Toxicity, Lipid Effect in Man

E. GREY DIMOND M.D.1, JOSEFINA CARAVACA PH.D.1, and ALBERTO BENCHIMOL M.D.1

1 From the Institute for CardioPulmonary Diseases, Scripps Clinic and Research Foundation, La Jolla, California

Vanadium, as ammonium vanadyl tartrate, was given orally to six subjects. The total number of days of therapy were forty-five, sixty-three, forty-seven, fifty-eight, forty-seven and sixty-eight, and the total amount of vanadium salt administered was 3,450, 4,325, 3,600, 3,875, 1,575 and 4,225 mg. Except for cramps and diarrhea, which occurred when large doses were given, no toxic effects were noted. Varying amounts of vanadium excreted in the urine suggest unpredictable absorption. Statistical changes did not occur in blood lipids, phospholipids, triglycerides and cholesterol, and 17-ketosteroid and 17-hydroxycorticosteroid levels were unchanged.







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