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American Journal of Clinical Nutrition, Vol 10, 257-260, Copyright © 1962 by The American Society for Clinical Nutrition, Inc.

Thiamine Therapy in Relation to the Glucose Oxidative Pathway in Human Red Cells

CHARLES E. SHIELDS M.C.1

1 From the Kimbrough Army Hospital, Fort George, G. Meade, Maryland

In the metabolism of glucose, the hexomonophosphate or direct glucose oxidative pathway involves the formation of pentoses which require the presence of thiamine pyrophosphate for further reaction. The pentose level was studied in human red cells. Normal patients had values of 130.0 ± 5.1 µg. This level could be increased by in vitro addition of TPN, which apparently facilitated the pentose shunt, and thiaminase which inactivated thiamine. Thiamine therapy depressed the pentose level to an average of 112.8 ± 5.5 µg. regardless of the route or dosage over 25 mg. Similar levels were found in patients with infectious hepatitis and lung carcinoma. These studies demonstrated that human red cell pentose determinations varied inversely with alterations of thiamine activity.






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Copyright © 1962 by The American Society for Nutrition